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A Europe‐wide assessment of current medication choices in Huntington's disease by Josef Priller; Daniel Ecker; Bernhard Landwehrmeyer; David Craufurd is a Medicine article available to read on EtoBox.

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s disease (HD) is a fatal neurodegenerative disorder, which usually manifests in middle age with motor, psychiatric and/or cognitive disturbances. In his recent review, Francis Walker stated that medical treatment of HD has made little progress in the past 20 years. 1 Despite a large number of reports on pharmacological interventions in HD, no treatment recommendation could be made in a recent evaluation of 20 randomized controlled clinical trials. 2 While symptomatic treatment of HD has been reviewed, 3 a systematic evaluation of current prescription practices is missing. We have analyzed the use of symptomatic treatment for HD based on more than 7,000 entries in the European HD REGISTRY between 2004 and 2007. The REGISTRY collects data from centres across Europe with particular expertise in HD. As many as 1,796 of 2,128 registered HD patients (84%) received symptomatic treatment. About 1,058 patients (50%) were treated for depression and 596 (28%) received antichorea medication. Among the other common indications, 268 patients (13%) were treated for irritability and aggression, 188 (9%) for sleep disturbance, and 152 (7%) for psychosis. Fewer than 2% of patients received medicati

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Author

Josef Priller; Daniel Ecker; Bernhard Landwehrmeyer; David Craufurd

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0885-3185)

Published

2008

Language

EN

Field

Medicine (Health Sciences)