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NGF-potentiating vibsane-type diterpenoids from Viburnum sieboldii by Miwa Kubo; Yoshiko Kishimoto; Kenichi Harada; Hideaki Hioki; Yoshiyasu Fukuyama is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is NGF-potentiating vibsane-type diterpenoids from Viburnum sieboldii about?

Six new vibsane-type diterpenoids, named neovibsanin O (1), neovibsanin M (2), neovibsanin L (3), (8Z)-neovibsanin M (4), 15-O-methylvibsanin H (5), and 5-epi-15-O-methylvibsanin H (6), were isolated from the leaves of Viburnum sieboldii by bioassay-guided fractionation using NGF-differentiated PC12 cells. The structures of 1-6 were established by analyzing their spectroscopic data and comparing their NMR data with those of previously reported vibsane-type diterpenoids. Compounds 3 and 4, and the known vibsane-type diterpenoids neovibsanins A (7) and B (8) significantly enhanced the neurite outgrowth of NGF-mediated PC12 cells at concentrations ranging from 20 to 40 microM.

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Author

Miwa Kubo; Yoshiko Kishimoto; Kenichi Harada; Hideaki Hioki; Yoshiyasu Fukuyama

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)

Published

2010

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)