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Immunoglobulin G1 Fc glycosylation as an early hallmark of severe COVID-19 by Pongracz, Tamas (author);Nouta, Jan (author);Wang, Wenjun (author);van Meijgaarden, Krista E. (author);Linty, Federica (author);Vidarsson, Gestur (author);Joosten, Simone A. (author);Ottenhoff, Tom H.M. (author);Hokke, Cornelis H. (author);de Vries, Jutte J.C. (author);Arbous, Sesmu M. (author);Roukens, Anna H.E. (author);Wuhrer, Manfred (author) is a Medicine article available to read on EtoBox.

What is Immunoglobulin G1 Fc glycosylation as an early hallmark of severe COVID-19 about?

Background Immunoglobulin G1 (IgG1) effector functions are impacted by the structure of fragment crystallizable (Fc) tail-linked N-glycans. Low fucosylation levels on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein-specific IgG1 has been described as a hallmark of severe coronavirus disease 2019 (COVID-19) and may lead to activation of macrophages via immune complexes thereby promoting inflammatory responses, altogether suggesting involvement of IgG1 Fc glycosylation modulated immune mechanisms in COVID-19. Methods In this prospective, observational single center cohort study, IgG1 Fc glycosylation was analyzed by liquid chromatography-mass spectrometry following affinity capturing from serial plasma samples of 159 SARS-CoV-2 infected hospitalized patients. Findings At baseline close to disease onset, anti-S IgG1 glycosylation was highly skewed when compared to total plasma IgG1. A rapid, general reduction in glycosylation skewing was observed during the disease course. Low anti-S IgG1 galactosylation and sialylation as well as high bisection were early hallmarks of disease severity, whilst high galactosylation and sialylation and low bisection were f

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Author
Pongracz, Tamas (author);Nouta, Jan (author);Wang, Wenjun (author);van Meijgaarden, Krista E. (author);Linty, Federica (author);Vidarsson, Gestur (author);Joosten, Simone A. (author);Ottenhoff, Tom H.M. (author);Hokke, Cornelis H. (author);de Vries, Jutte J.C. (author);Arbous, Sesmu M. (author);Roukens, Anna H.E. (author);Wuhrer, Manfred (author)
Publisher
Elsevier BV
Published
2022
Language
EN
Field
Medicine (Life Sciences)

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