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Glucagon-like peptide-1 analogues and risk of breast cancer in women with type 2 diabetes: population based cohort study using the UK Clinical Practice Research Datalink by Blánaid M Hicks; Hui Yin; Oriana H Y Yu; Michael N Pollak; Robert W Platt; Laurent Azoulay is a Health Professions article available to read on EtoBox.
What is Glucagon-like peptide-1 analogues and risk of breast cancer in women with type 2 diabetes: population based cohort study using the UK Clinical Practice Research Datalink about?
## Objective: To determine whether the use of glucagon-like peptide-1 (glp-1) analogues, compared with the use of dipeptidylpeptidase-4 (dpp-4) inhibitors, is associated with an increased risk of incident breast cancer in patients with type 2 diabetes. ## Design: Population based cohort study. ## Setting: Clinical practice research datalink, uk. ## Participants: 44 984 women aged at least 40 years, who were newly treated with glucose lowering drugs between 1 january 2007 and 31 march 2015, with follow-up until 31 march 2016. ## Main outcomes and measures: Time varying use of glp-1 analogues compared with use of dpp-4 inhibitors, with exposures lagged by one year for latency purposes. time dependent cox proportional hazards models were used to estimate adjusted hazard ratios with 95% confidence intervals of incident breast cancer associated with use of glp-1 analogues overall, by cumulative duration of use, and time since initiation. ## Results: The cohort was followed for a mean of 3.5 years (standard deviation 2.2), with 549 incident events of breast cancer recorded (crude incidence 3.5 (95% confidence interval 3.3 to 3.8) per 1000 person years). overall, compared with use of dpp-
Who reads Glucagon-like peptide-1 analogues and risk of breast cancer in women with type 2 diabetes: population based cohort study using the UK Clinical Practice Research Datalink?
It is typically read by researchers, students, and practitioners in Health Professions.
- Author
- Blánaid M Hicks; Hui Yin; Oriana H Y Yu; Michael N Pollak; Robert W Platt; Laurent Azoulay
- Publisher
- BMJ
- Published
- 2016
- Language
- EN
- Field
- Health Professions (Health Sciences)