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In silico design of recombinant multi-epitope vaccine against influenza A virus by Avisa Maleki; Giulia Russo; Giuseppe Alessandro Parasiliti Palumbo; Francesco Pappalardo is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is In silico design of recombinant multi-epitope vaccine against influenza A virus about?

## Abstract ## Background Influenza A virus is one of the leading causes of annual mortality. The emerging of novel escape variants of the influenza A virus is still a considerable challenge in the annual process of vaccine production. The evolution of vaccines ranks among the most critical successes in medicine and has eradicated numerous infectious diseases. Recently, multi-epitope vaccines, which are based on the selection of epitopes, have been increasingly investigated. ## Results This study utilized an immunoinformatic approach to design a recombinant multi-epitope vaccine based on a highly conserved epitope of hemagglutinin, neuraminidase, and membrane matrix proteins with fewer changes or mutate over time. The potential B cells, cytotoxic T lymphocytes (CTL), and CD4 T cell epitopes were identified. The recombinant multi-epitope vaccine was designed using specific linkers and a proper adjuvant. Moreover, some bioinformatics online servers and datasets were used to evaluate the immunogenicity and chemical properties of selected epitopes. In addition, Universal Immune System Simulator (UISS) in silico trial computational framework was run after influenza exposure and recombin

Who reads In silico design of recombinant multi-epitope vaccine against influenza A virus?

Author

Avisa Maleki; Giulia Russo; Giuseppe Alessandro Parasiliti Palumbo; Francesco Pappalardo

Publisher

Springer Science and Business Media LLC

Published

2022

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)