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NH4Cl/SiO2 (mmol) Time (h) Yield (%)a 1 0.5 1 2 3 4 5 2 2 2 2 2 2 2 No reaction No reaction 75 80 85 90 a Isolated yields. As shown in Table 2, the amidation reaction of benzoic acid did not proceed in the absence of NH4Cl/SiO2 or with substoichiometric amounts of it. However, the reaction was completed within 2 h to afford the amide in good to excellent yields when at least 1 mmol of NH4Cl/SiO2 was used. The crude products were purified by recrystallization from ethanol or chromatography [

Author

Ahmed Elkamhawy

Language

EN