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Endotoxic and immunobiological activities of a chemically synthesized lipid A of Helicobacter pylori strain 206–1 by Tomohiko Ogawa; Yasuyuki Asai; Yasuhiro Sakai; Masato Oikawa; Koichi Fukase; Yasuo Suda; Shoichi Kusumoto; Toshihide Tamura is a Medicine article available to read on EtoBox.

What is Endotoxic and immunobiological activities of a chemically synthesized lipid A of Helicobacter pylori strain 206–1 about?

A synthetic lipid A of Helicobacter pylori strain 206-1 (compound HP206-1), which is similar to its natural lipid A, exhibited no or very low endotoxic activities as compared to Escherichia coli-type synthetic lipid A (compound 506). Furthermore, compound HP206-1 as well as its natural lipid A demonstrated no or very low mitogenic responses in murine spleen cell. On the other hand, compound HP206-1 showed a weaker but significant production of interleukin-8 in a gastric cancer cell line, MKN-1, in comparison with compound 506. Furthermore, compound HP206-1 exhibited induction of tumor necrosis factor-alpha production in human peripheral blood mononuclear cells and the cytokine production was clearly inhibited by mouse anti-human Toll-like receptor (TLR) 4 monoclonal antibody HTA125. Our findings indicate that the chemically synthesized lipid A, mimicking the natural lipid A portion of lipopolysaccharide from H. pylori strain 206-1, has a low endotoxic potency and immunobiological activities, and is recognized by TLR4.

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Author

Tomohiko Ogawa; Yasuyuki Asai; Yasuhiro Sakai; Masato Oikawa; Koichi Fukase; Yasuo Suda; Shoichi Kusumoto; Toshihide Tamura

Publisher

John Wiley and Sons; Oxford University Press; Wiley; Oxford University Press (OUP); Elsevier BV (ISSN 0928-8244)

Published

2003

Language

EN

Field

Medicine (Life Sciences)