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Drug-loaded biomaterials for orthopedic applications: A review by Divyanshu Aggarwal; Vinod Kumar; Siddharth Sharma is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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Drug-eluting implants are one of the leading implant technologies to facilitate the healing capacity of bones by eliminating implant-associated infections. Treatment of the infections like osteomyelitis, prevention of pathogen growth in the bone, and elimination of residual cancer cells, have become the predominant need of the orthopedic industry. Moreover, the mechanical compatibility of the implants to retain their strength under the corrosive environment of the body is one of the vital critical components needed to balance with biological properties. The drawbacks of permanent implants have already shifted the attention towards biodegradable materials due to various advantages, i.e., 1) eliminate the need for a second surgery and 2) Degradation rate, which will slowly transfer the load to the healing bone and reduces the problem of stress-shielding. However, implant-related infections are still a matter of concern despite these properties. The review focuses on highlighting various drug-loaded implant technologies investigated previously. The effects of different drugs to overcome the repercussions of bacterial colonies formed due to adherence of different bacteria over the surf

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Author

Divyanshu Aggarwal; Vinod Kumar; Siddharth Sharma

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)