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UHPLC-QTOF-MS/MS based phytochemical characterization and anti-hyperglycemic prospective of hydro-ethanolic leaf extract of Butea monosperma by Farooq, Muhammad Umar; Mumtaz, Muhammad Waseem; Mukhtar, Hamid; Rashid, Umer; Akhtar, Muhammad Tayyab; Raza, Syed Ali; Nadeem, Muhammad is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is UHPLC-QTOF-MS/MS based phytochemical characterization and anti-hyperglycemic prospective of hydro-ethanolic leaf extract of Butea monosperma about?
__Butea monosperma__ is one of the extensively used plants in traditional system of medicines for many therapeutic purposes. In this study, the antioxidant activity, __α__-glucosidase and __α__-amylase inhibition properties of freeze drying assisted ultrasonicated leaf extracts (hydro-ethanolic) of __B. monosperma__ have been investigated. The findings revealed that 60% ethanolic fraction exhibited high phenolic contents, total flavonoid contents, highest antioxidant activity, and promising __α__-glucosidase and __α__-amylase inhibitions. The UHPLC-QTOF-MS/MS analysis indicated the presence of notable metabolites of significant medicinal potential including apigenin, apigenin __C__-hexoside __C__-pentoside, apigenin __C__-hexoside __C__-hexoside, apigenin-6,8-di-__C__-pentoside and genistin etc., in __B. monosperma__ leave extract. Docking studies were carried out to determine the possible role of each phytochemical present in leaf extract. Binding affinity data and interaction pattern of all the possible phytochemicals in leaf extract of __B. monosperma__ revealed that they can inhibit __α__-amylase and __α__-glucosidase synergistically to prevent hyperglycemia.
Who reads UHPLC-QTOF-MS/MS based phytochemical characterization and anti-hyperglycemic prospective of hydro-ethanolic leaf extract of Butea monosperma?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Farooq, Muhammad Umar; Mumtaz, Muhammad Waseem; Mukhtar, Hamid; Rashid, Umer; Akhtar, Muhammad Tayyab; Raza, Syed Ali; Nadeem, Muhammad
- Publisher
- Springer Science and Business Media LLC; London: Nature Publishing Group; [London]: Springer Nature; Nature Publishing Group; Society for Mining, Metallurgy and Exploration Inc.; Research Square; Springer Nature; Island Press (ISSN 2045-2322)
- Published
- 2020
- Language
- EN
- ISBN
- 9784159802067
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)