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Adjuvant therapy of melanoma with interferon-alpha-2b is associated with mania and bipolar syndromes : Gabapentin may serve as a mood stabilizer by Donna B. Greenberg; Eric Jonasch; Michele A. Gadd; Bonita F. Ryan; James R. Everett; Arthur J. Sober; Martin A. Mihm; Kenneth K. Tanabe; Mark Ott; Frank G. Haluska is a Medicine article available to read on EtoBox.
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## BACKGROUND. The use of a high dose regimen of interferon-alpha-2b (IFN) has recently been demonstrated to benefit patients with resected high risk melanoma. The incidence of melanoma is rising rapidly, and the use of this regimen is becoming increasingly common. IFN has been associated with numerous psychiatric side effects. ## METHODS. The authors describe four melanoma patients treated with adjuvant IFN who developed a manic-depressive syndrome or mood instability with therapy, and they review the literature on mania and the mixed affective syndromes associated with IFN. ## RESULTS. The authors suggest that IFN may induce a mixed affective instability, and that patients risk developing hypomania or mania as IFN doses fluctuate or as IFN-induced depression is treated with antidepressants alone. Mania is particularly associated with dose reductions or pauses in IFN treatment. The risk of mood fluctuation continues after treatment with IFN stops, and patients should be monitored for 6 months following completion of therapy. Gabapentin appeared effective as monotherapy for acute mania, as an antianxiety agent, as a hypnotic, and as a mood stabilizer in these individual cases. ## C
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- Author
- Donna B. Greenberg; Eric Jonasch; Michele A. Gadd; Bonita F. Ryan; James R. Everett; Arthur J. Sober; Martin A. Mihm; Kenneth K. Tanabe; Mark Ott; Frank G. Haluska
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)
- Published
- 2000
- Language
- EN
- Field
- Medicine (Health Sciences)