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Customized Dose Prescription for Permanent Prostate Brachytherapy: Insights From a Multicenter Analysis of Dosimetry Outcomes by Nelson N. Stone; Louis Potters; Brian J. Davis; Jay P. Ciezki; Michael J. Zelefsky; Mack Roach; Paul A. Fearn; Michael W. Kattan; Richard G. Stock is a Medicine article available to read on EtoBox.
What is Customized Dose Prescription for Permanent Prostate Brachytherapy: Insights From a Multicenter Analysis of Dosimetry Outcomes about?
## Purpose: To investigate the biochemical control rate in patients undergoing permanent prostate brachytherapy as a function of the biologically effective dose (bed) and risk group. ## Methods and materials: Six centers provided data on 3,928 permanent brachytherapy patients with postimplant dosimetry results. the mean prostate-specific antigen level was 8.9 ng/ml. (125)i was used in 2,293 (58%), (103)pd in 1,635, and supplemental external beam radiotherapy in 882 (22.5%) patients. the patients were stratified into low- (n = 2,188), intermediate- (n = 1,188), and high- (n = 552) risk groups and into three bed groups of 200 gy (n = 1,115). freedom from biochemical disease progression (biochemical freedom from failure [bfff]) was determined using the american society for therapeutic radiology oncology and phoenix definitions and calculated using the kaplan-meier method, with factors compared using the log-rank test. ## Results: The 10-year prostate-specific antigen bfff rate for the american society for therapeutic radiology oncology and phoenix definitions was 79.2% and 70%, respectively. the corresponding bfff rates for the low-, intermediate-, and high-risk groups was 84.1% and
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- Author
- Nelson N. Stone; Louis Potters; Brian J. Davis; Jay P. Ciezki; Michael J. Zelefsky; Mack Roach; Paul A. Fearn; Michael W. Kattan; Richard G. Stock
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)
- Published
- 2007
- Language
- EN
- Field
- Medicine (Health Sciences)