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Natural terpenes: Self-assembly and membrane partitioning by A.del V. Turina; M.V. Nolan; J.A. Zygadlo; M.A. Perillo is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Natural terpenes: Self-assembly and membrane partitioning about?

Monoterpenes (MTs) are highly hydrophobic substances present in essential oils. They cover a wide spectrum of biological effects with a membrane interaction as a common point. Here we studied the surface activity of camphor, cineole, thymol, menthol and geraniol, and their ability to reach and incorporate into model membranes affecting some features of their dynamic organization. All the MTs studied self-aggregated in water with critical micellar concentrations (CMC) between 3 and 8 microM. Their octanol-water and membrane-water partition coefficients were correlated with one another. They all penetrated in monomolecular layers of dipalmitoyl-phosphatildylcholine at the air-water interface, even at surface pressures (pi) above the equilibrium lateral pressure of bilayers; thymol exhibited the highest (61.3 mN/m) and camphor the lowest (37 mN/m) pi(cut-off) value. They affected the self-aggregation of Triton X-100, increasing its CMC from 0.16 mM in the absence of MTs up to 0.68 mM (e.g. for geraniol), and the topology of sPC vesicles, increasing its surface curvature, suggesting their location at the polar head group region of the membrane. The latter was supported by their ability

Who reads Natural terpenes: Self-assembly and membrane partitioning?

Author

A.del V. Turina; M.V. Nolan; J.A. Zygadlo; M.A. Perillo

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0301-4622)

Published

2006

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)