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What is APOBEC about?

The review discusses the dual role of the APOBEC family of cytidine deaminases in breast cancer, highlighting their contributions to tumor evolution and therapeutic response. It emphasizes how APOBEC-mediated mutagenesis drives tumor heterogeneity and influences immune responses, while also being associated with treatment resistance. The authors propose the use of APOBEC mutational signatures as predictive biomarkers for immunotherapy efficacy and suggest therapeutic strategies that leverage APOBEC activity

Author

lucas reinier

Language

EN