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Characterizing Behavioral and Cognitive Dysexecutive Changes in Progressive Supranuclear Palsy by David Millar; Philipa Griffiths; Adam J. Zermansky; David J. Burn is a Medicine article available to read on EtoBox.

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## Abstract Frontal lobe dysfunction is a prominent feature of many neurological disorders. Early diagnosis may be enhanced by establishing a profile of cognitive, behavioral, and emotional change. Traditional psychometric assessment focuses on cognitive dysfunction and fails to identify behavioral changes, particularly those associated with orbitofrontal dysfunction. We examined progressive supranuclear palsy (PSP), a prototypical subcortical dementia with frontal features, using commonly available neuropsychological measures and a modification of the Katz Adjustment Scale‐Relatives (KAS‐R), an instrument first developed to assess dysexecutive changes in head‐injured patients. Executive tests identified deficits in reasoning, planning, set shifting, verbal fluency, information processing speed, and response initiation. On the KAS‐R, changes in apathy, social withdrawal, and independence were observed, with little change in belligerence, social irresponsibility, uncooperativeness, obstreperousness, anxiety, and depression. The results show the potential utility of this instrument in characterizing behavioral and emotional changes associated with frontal lobe dysfunction in neurodeg

Who reads Characterizing Behavioral and Cognitive Dysexecutive Changes in Progressive Supranuclear Palsy?

Author

David Millar; Philipa Griffiths; Adam J. Zermansky; David J. Burn

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0885-3185)

Published

2006

Language

EN

Field

Medicine (Health Sciences)