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This review discusses the adaptation mechanisms of the COPII coat for the export of large cargoes from the endoplasmic reticulum (ER), focusing on the challenges posed by bulky proteins like procollagens. It highlights recent findings that suggest a flexible COPII architecture, involving various cargo-specific regulators and alternative transport pathways, to accommodate the diverse demands of large cargo secretion. The role of key proteins such as TANGO1 and other adaptors in facilitating this process is e

Author

youshust1991

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EN