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Effects of berberine and barberry on selected inflammatory biomarkers in adults: A systematic review and dose–response meta‐analysis of randomized clinical trials by Yasaman Vahedi‐Mazdabadi; Hossein Shahinfar; Mohammad Toushih; Farzad Shidfar is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract The previous meta‐analysis showed an advantageous effect of berberine supplementation on interleukin 6 (IL‐6), tumor necrosis factor‐α (TNF‐α), and serum C‐reactive protein (CRP) concentrations; however, it is unknown the dosage that this component influences inflammatory biomarkers. A comprehensive search was done in Scopus, PubMed, and Web of Science until September 2022 to find randomized controlled trials (RCT) that assessed the effects of berberine/barberry on IL‐6, TNF‐α, and CRP in adults but not trials without a control group. Studies bias was assessed using RoB 2. A random‐effects model was performed to calculate the weighted mean difference (WMD). A dose‐dependent effect was calculated. Eighteen clinical trials with 1600 participants were included in the current meta‐analysis. These interventions significantly mitigate IL‐6 levels (−1.18 pg/mL), TNF‐α levels (−3.72 pg/mL), and CRP levels (−1.33 mg/L). In addition, the non‐linear analysis showed a significant lowering effect of berberine/barberry on IL‐6 and TNF‐α levels in doses <1000 mg/day and less than 5 weeks of intervention. There are limitations to our findings, including low‐quality studies and signific

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Author

Yasaman Vahedi‐Mazdabadi; Hossein Shahinfar; Mohammad Toushih; Farzad Shidfar

Publisher

Wiley

Published

2023

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)