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Fasting Triacylglycerol Status, but Not Polyunsaturated/saturated Fatty Acid Ratio, Influences the Postprandial Response to a Series of Oral Fat Tolerance Tests by Mark J. Dekker; Amanda J. Wright; Vera C. Mazurak; Alejandro G. Marangoni; James W.E. Rush; Terry E. Graham; Lindsay E. Robinson is a Medicine article available to read on EtoBox.
What is Fasting Triacylglycerol Status, but Not Polyunsaturated/saturated Fatty Acid Ratio, Influences the Postprandial Response to a Series of Oral Fat Tolerance Tests about?
Elevated postprandial lipemia is emerging as a risk factor for obesity-related chronic diseases, such as type 2 diabetes and cardiovascular disease, and is associated with alterations in several metabolic biomarkers of disease. Our goal was to examine the effects of specific polyunsaturated/saturated fatty acid (P/S) ratios on postprandial triacylglycerol (TAG) concentrations and metabolic biomarkers in men with different fasting TAG concentrations through a series of oral fat tolerance tests (OFTT) consisting solely of emulsified lipid. Otherwise healthy men with high (N1.69 mmol/L) fasting TAG (HTAG, n=8) and low fasting TAG (LTAG, n=8) underwent three OFTTs with specific P/S ratios of 0.2, 1.0 and 2.0, respectively, and a total lipid load of 1 g/kg subject body mass. All subjects received each treatment separated by at least 1 week. Postprandial plasma TAG fatty acid composition reflected fatty acids present in the OFTT. All other metabolic responses were independent of the P/S ratio ingested. An accelerated increase in postprandial TAGs was observed in HTAG compared to LTAG. Interleukin (IL)-6 and soluble intercellular adhesion molecule (sICAM)-1 were significantly elevated in
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- Author
- Mark J. Dekker; Amanda J. Wright; Vera C. Mazurak; Alejandro G. Marangoni; James W.E. Rush; Terry E. Graham; Lindsay E. Robinson
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0955-2863)
- Published
- 2009
- Language
- EN
- Field
- Medicine (Health Sciences)