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Lack of efficacy: case report A 10-year-old girl exhibited lack of efficacy during treatment with immune-globulin and aspirin for multisystem inflammatory syndrome in children (MIS-C) [route and all dosages not stated]. The girl who had history of febrile seizures, presented to the emergency department after having flu-like symptoms, generalised tonic-clonic seizure and temperature of 104.0°F for two days. Severe acute respiratory syndrome coronavirus 2 assay (SARS-CoV-2) was positive. She was admitted for evaluation and empiric treatment for evolving MIS-C or infection. For three days she remained febrile. Her laboratory examination were significant for up-trending inflammatory markers, including erythrocyte sedimentation rate, C-reactive protein, D-Dimer and ferritin, and an elevated white blood cell count. To treat the bacterial infection vancomycin and ceftriaxone were used. Treatment with methylprednisolone, aspirin and immune-globulin were used to treat MIS-C. Her neurological condition worsened and she became perseverative, disoriented, had difficulty following commands, slowed in response-times, and developed a new high-amplitude tremor of her hands and tongue. Electroencep

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Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN

Field

Medicine (Health Sciences)