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Can I read MiCEE is a ncRNA-protein complex that mediates epigenetic silencing and nucleolar organization on EtoBox?
MiCEE is a ncRNA-protein complex that mediates epigenetic silencing and nucleolar organization by Indrabahadur Singh; Adriana Contreras; Julio Cordero; Karla Rubio; Stephanie Dobersch; Stefan Günther; Sylvia Jeratsch; Aditi Mehta; Marcus Krüger; Johannes Graumann; Werner Seeger; Gergana Dobreva; Thomas Braun; Guillermo Barreto is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is MiCEE is a ncRNA-protein complex that mediates epigenetic silencing and nucleolar organization about?
The majority of the eukaryotic genome is transcribed into noncoding RNAs (ncRNAs), which are important regulators of different nuclear processes by controlling chromatin structure. However, the full extent of ncRNA function has remained elusive. Here we deciphered the function of the microRNA Mirlet7d as a key regulator of bidirectionally transcribed genes. We found that nuclear Mirlet7d binds ncRNAs expressed from these genes. Mirlet7d-ncRNA duplexes are further bound by C1D, which in turn targets the RNA exosome complex and the polycomb repressive complex 2 (PRC2) to the bidirectionally active loci. The exosome degrades the ncRNAs, whereas PRC2 induces heterochromatin and transcriptional silencing through EZH2. Moreover, this multicomponent RNA-protein complex, which we named MiCEE, tethers the regulated genes to the perinucleolar region and thus is required for proper nucleolar organization. Our study demonstrates that the MiCEE complex mediates epigenetic silencing of bidirectionally expressed genes and global genome organization.
Who reads MiCEE is a ncRNA-protein complex that mediates epigenetic silencing and nucleolar organization?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Indrabahadur Singh; Adriana Contreras; Julio Cordero; Karla Rubio; Stephanie Dobersch; Stefan Günther; Sylvia Jeratsch; Aditi Mehta; Marcus Krüger; Johannes Graumann; Werner Seeger; Gergana Dobreva; Thomas Braun; Guillermo Barreto
- Publisher
- Nature Publishing Group; Springer Science and Business Media LLC (ISSN 1061-4036)
- Published
- 2018
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)