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Can I read The role of regulator FucP in Edwardsiella tarda pathogenesis and the inflammatory cytokine response in tilapia on EtoBox?
The role of regulator FucP in Edwardsiella tarda pathogenesis and the inflammatory cytokine response in tilapia by Jiayan Wu; Guangbin Liu; Yongcan Sun; Xuepeng Wang; Hao Fang; Heng Jiang; Zhiming Guo; Jinggang Dong is a Immunology and Microbiology article available to read on EtoBox.
What is The role of regulator FucP in Edwardsiella tarda pathogenesis and the inflammatory cytokine response in tilapia about?
The animal intestine provides a competitive environment for the microbiota. Successful colonization by pathogens requires sensing chemical signals to regulate the expression of virulence genes. Some bacteria rely on a two-component chemical signal transduction system, named FusKR, to regulate virulence genes expression by intestinal fucose. Here we construct the fucP gene deletion strain prove FucP regulation of the T3SS in E. tarda. The result showed that the mutant strain had down-regulated significantly the gene expression of FusKR and T3SS compared to the wild-type strain (P < 0.05). This mutant strain significantly increased LD in zebrafish compared to the wild-type strain (P < 0.05), and significantly decreased penetration and motility in mucin than the wild-type strain (P < 0.05). Meanwhile, tilapia infected with mutant strain show significantly reduced E. tarda adherence and colonization than those infected with the wild-type strain (P < 0.05). Fish infected with EIB202 and ΔfucP showed significantly higher (P 0.05) in all groups. Fish infected with EIB202 showed significantly higher (P 0.05) in the whole observed period. In addition, Fish infected with EIB202 showed si
Who reads The role of regulator FucP in Edwardsiella tarda pathogenesis and the inflammatory cytokine response in tilapia?
It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- Jiayan Wu; Guangbin Liu; Yongcan Sun; Xuepeng Wang; Hao Fang; Heng Jiang; Zhiming Guo; Jinggang Dong
- Publisher
- Elsevier Science; Elsevier ; Elsevier Inc.; Elsevier BV (ISSN 1050-4648)
- Published
- 2018
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)