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Vascular mimicry: Triggers, molecular interactions and in vivo models by Stephen L. Wechman; Luni Emdad; Devanand Sarkar; Swadesh K. Das; Paul B. Fisher is a book available to read on EtoBox.

What is Vascular mimicry: Triggers, molecular interactions and in vivo models about?

Vascular mimicry is induced by a wide array of genes with functions related to cancer stemness, hypoxia, angiogenesis and autophagy. Vascular mimicry competent (VM-competent) cells that form de novo blood vessels are common in solid tumors facilitating tumor cell survival and metastasis. VM-competent cells display increased levels of vascular mimicry selecting for stem-like cells in an O-gradient-dependent manner in deeply hypoxic tumor regions, while also aiding in maintaining tumor cell metabolism and stemness. Three of the principal drivers of vascular mimicry are EphA2, Nodal and HIF-1α, however, directly or indirectly many of these molecules affect VE-Cadherin (VE-Cad), which forms gap-junctions to bind angiogenic blood vessels together. During vascular mimicry, the endothelial-like functions of VM-competent cancer stem cells co-opt VE-Cad to bind cancer cells together to create cancer cell-derived blood conducting vessels. This process potentially compensates for the lack of access to blood and nutrient in avascular tumors, simultaneously providing nutrients and enhancing cancer invasion and metastasis. Current evidence also supports that vascular mimicry promotes cancer mali

Author

Stephen L. Wechman; Luni Emdad; Devanand Sarkar; Swadesh K. Das; Paul B. Fisher

Publisher

Elsevier

Published

2020

Language

EN