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Circulating Osteocalcin‐Positive Cells as a Novel Diagnostic Biomarker for Bone Metastasis in Breast Cancer Patients by Lee, KyungâHun; Lee, Kyoung Jin; Kim, TaeâYong; Hutomo, Febby; Sun, Hyun Jin; Cheon, Gi Jeong; In Park, Serk; Cho, Sun Wook; Im, SeockâAh is a Medicine article available to read on EtoBox.
What is Circulating Osteocalcin‐Positive Cells as a Novel Diagnostic Biomarker for Bone Metastasis in Breast Cancer Patients about?
## ABSTRACT Current diagnosis of bone metastasis (BM) in breast cancer relies on structural changes of bone that occur only in the advanced stage. A sensitive biomarker for detecting early progression of bone metastasis is urgently required. We performed clinical and preclinical studies to investigate diagnostic value of circulating osteocalcin‐positive cells (cOC) in breast cancer bone metastasis. Metastatic breast cancer patients (n = 92) with or without bone metastasis (ie, BM^+^ or BM^–^) were enrolled, and cOC were measured at enrollment. Patients were followed up for bone metastasis progression for 18 months. BM^+^ patients (n = 59) were divided into progressive (PD) or stable disease (SD) groups, based on imaging studies at the end of the 18‐month study. The PD group had higher baseline cOC compared with the SD group. Furthermore, higher cOC resulted in reduced BM progression‐free survival. Three patients in the BM^–^ group (n = 33) developed new BM during the 18‐month study, and these patients had a higher level of baseline cOC compared with the remaining BM^–^ patients. In murine preclinical studies, cOC increased at early time points when micro‐metastases were evident onl
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- Author
- Lee, KyungâHun; Lee, Kyoung Jin; Kim, TaeâYong; Hutomo, Febby; Sun, Hyun Jin; Cheon, Gi Jeong; In Park, Serk; Cho, Sun Wook; Im, SeockâAh
- Publisher
- American Society for Bone and Mineral Research; Wiley (John Wiley & Sons); Wiley-Blackwell; Wiley (ISSN 0884-0431)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)