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Electroenzymatic synthesis of l-DOPA by Kyoungseon Min; Don-Hee Park; Young Je Yoo is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Electroenzymatic synthesis of l-DOPA about?

Parkinson's disease is caused by a deficiency of the neurotransmitter dopamine. Since l-DOPA (l-3,4dihydroxyphenylalanine) is a precursor of dopamine and can pass across the blood-brain barrier, it has been used as a treatment for Parkinson's disease. Hundreds tons of l-DOPA are produced per year, and most of the current supply is produced by a chemical method of asymmetric synthesis. However, the chemical process for l-DOPA synthesis requires an expensive metal catalyst and shows low conversion rates and low enantioselectivity. In this study, we developed a novel technology for the production of l-DOPA, an electroenzymatic synthesis with a tyrosinase-immobilized cathode under the reduction potential of DOPAquinone, which is -530 mV. Compared to other approaches for l-DOPA synthesis reported previously, this electroenzymatic system showed the highest conversion rate and a highly enhanced productivity of up to 95.9% and 47.27 mg l -1 h -1 , respectively.

Who reads Electroenzymatic synthesis of l-DOPA?

Author

Kyoungseon Min; Don-Hee Park; Young Je Yoo

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0168-1656)

Published

2010

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)