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Morphine Injected Into the Paraventricular Nucleus of the Hypothalamus Prevents Noncontact Penile Erections and Impairs Copulation: Involvement of Nitric Oxide by Maria Rosaria Melis; Salvatora Succu; Maria Sabrina Spano; Antonio Argiolas is a Neuroscience article available to read on EtoBox.

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## Abstract Male rats show four to six penile erection episodes when put in the presence of an inaccessible receptive female for 80 min. These noncontact erections occur concomitantly with an increase in nitric oxide production in the paraventricular nucleus of the hypothalamus. This is shown by the increases in the NO~2~^–^ and NO~3~^–^ concentrations in the paraventricular dialysate obtained from these males by in vivo microdialysis. The NO~2~^–^ concentration increased from 0.75 ± 0.10 μm to 2.89 ± 0.39 μm and that of NO~3~^–^ from 4.13 ± 0.58 μm to 9.5 ± 1.2 μm. Morphine (0.5, 1 and 5 μg), given unilaterally into the paraventricular nucleus 15 min before the introduction of the receptive female, prevented the NO~2~^–^ and NO~3~^–^ increases, and noncontact erections, dose‐dependently. In contrast, the κ opioid receptor agonist U‐69 593 (5 μg) was ineffective. The effects of morphine on NO~2~^–^ and NO~3~^–^, and on noncontact erections, were prevented by the opiate receptor antagonist naloxone (10 μg) injected into the paraventricular nucleus 15 min before morphine. The NO~2~^–^ and NO~3~^–^ concentrations were also increased in the paraventricular dialysate of male rats during

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Author

Maria Rosaria Melis; Salvatora Succu; Maria Sabrina Spano; Antonio Argiolas

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0953-816X)

Published

1999

Language

EN

Field

Neuroscience (Life Sciences)