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Risk factors for atopic dermatitis in infants at high risk of allergy: the PIAMA study by M. Kerkhof; L. P. Koopman; R. T. Van Strien; A. Wijga; H. A. Smit; R. C. Aalberse; H. J. Neijens; B. Brunekreef; D. S. Postma; J. Gerritsen; the PIAMA study group is a Medicine article available to read on EtoBox.

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## Summary **Background** It has been suggested that the period immediately after birth is a sensitive period for the development of atopic disease. **Objective** We investigated whether birth characteristics and environmental factors are associated with the development of atopic dermatitis in the first year of life. **Methods** Seventy‐six children with and 228 without atopic dermatitis, all children of mothers with respiratory allergy or asthma (PIAMA birth cohort study) were included in the study. Atopic dermatitis was defined as a positive history of an itchy skin condition with at least two of the following characteristics: visible dermatitis, history of outer arms/leg involvement, or general dry skin. Multiple logistic regression analysis was performed to study the independent effects of various risk factors. **Results** A birth weight 4000 g compared to 3000–4000 g was a significant risk factor for atopic dermatitis (odds ratio (OR)=2.4; 95% CI: 1.1–5.1) as was day care attendance (OR=2.9; 95% CI: 1.5–5.9). Exclusive breastfeeding in the first 3 months was negatively associated with atopic dermatitis (OR=0.6; 95% CI: 0.3–1.2), especially with visible dermatitis (OR=0.4; 95%

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Author

M. Kerkhof; L. P. Koopman; R. T. Van Strien; A. Wijga; H. A. Smit; R. C. Aalberse; H. J. Neijens; B. Brunekreef; D. S. Postma; J. Gerritsen; the PIAMA study group

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0954-7894)

Published

2003

Language

EN

Field

Medicine (Health Sciences)