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Light chains of mammalian cytoplasmic dynein: identification and characterization of a family of LC8 light chains by Matthew J. Wilson; Mark W. Salata; Stephen J. Susalka; K. Kevin Pfister is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Light chains of mammalian cytoplasmic dynein: identification and characterization of a family of LC8 light chains about?
## Abstract Cytoplasmic dynein is a large multisubunit motor protein that moves various cargoes toward the minus ends of microtubules. In addition to the previously identified heavy, intermediate, and light intermediate chains, it has recently been recognized that cytoplasmic dynein also has several light chain subunits with apparent molecular weights between 8–20 kDa. To systematically identify the light chains of purified rat brain cytoplasmic dynein, peptide sequences were obtained from each light chain band resolved by gel electrophoresis. Both members of the tctex1 light chain family, tctex1 and rp3, were identified in a single band. Only one member of the roadblock family, roadblock‐2, was found. Two members of the LC8 family were resolved as separate bands, the previously identified LC8 subunit, and a second novel cytoplasmic dynein family member, LC8b. The tissue distribution of these two dynein LC8 subunits differed, although LC8b was the major family member in brain. Database searches found that both LC8a and LC8b were also present in several mammalian species, and a third mammalian LC8 sequence, LC8c was found in the human database. The amino acid sequences of both LC8a
Who reads Light chains of mammalian cytoplasmic dynein: identification and characterization of a family of LC8 light chains?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Matthew J. Wilson; Mark W. Salata; Stephen J. Susalka; K. Kevin Pfister
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0886-1544)
- Published
- 2001
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)