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Environmental Enrichment Reverses Cognitive and Molecular Deficits Induced by Developmental Lead Exposure by Tomás R. Guilarte; Christopher D. Toscano; Jennifer L. McGlothan; Shelley A. Weaver is a Medicine article available to read on EtoBox.
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## Abstract Long‐term deficits in cognitive function are the principal effects of lead (Pb^2+^) exposure in children and can be modeled in experimental animals. Current therapeutic approaches in the treatment of childhood Pb^2+^ intoxication are not effective in reversing learning deficits once they have occurred. We report that environmental enrichment reverses long‐term deficits in spatial learning produced by developmental Pb^2+^ exposure in rats. Enhanced learning performance of Pb^2+^‐exposed animals reared in an enriched environment was associated with recovery of deficits in __N‐__methyl‐D‐aspartate receptor subunit 1 (NR1) mRNA and induction of brain‐derived neurotrophic factor (BDNF) mRNA in the hippocampus. The effect of environmental enrichment on NR1 and BDNF gene expression was specific to Pb^2+^‐exposed animals and was present in the absence of changes in the NR2B subunit of the __N‐__methyl‐D‐aspartate receptor, GluR1, αCamKII, or PSD‐95 gene expression measured in the same animals. Our findings demonstrate that the learning impairments and NR1 subunit mRNA deficits resulting from developmental Pb^2+^ exposure are reversible if the animals are provided with an enrich
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- Author
- Tomás R. Guilarte; Christopher D. Toscano; Jennifer L. McGlothan; Shelley A. Weaver
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0364-5134)
- Published
- 2002
- Language
- EN
- Field
- Medicine (Health Sciences)