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The unique expression profile of FAM19A1 in the mouse brain and its association with hyperactivity, long-term memory and fear acquisition by Yong, Hyo Jeong; Ha, Nui; Cho, Eun Bee; Yun, Seongsik; Kim, Hyun; Hwang, Jong-Ik; Seong, Jae Young is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is The unique expression profile of FAM19A1 in the mouse brain and its association with hyperactivity, long-term memory and fear acquisition about?
Neurodevelopment and mature brain function are spatiotemporally regulated by various cytokines and chemokines. The chemokine-like neuropeptide FAM19A1 is a member of family with sequence similarity 19 (FAM19), which is predominantly expressed in the brain. Its highly conserved amino acid sequence among vertebrates suggests that FAM19A1 may play important physiological roles in neurodevelopment and brain function. Here we used a __LacZ__ reporter gene system to map the expression pattern of the __FAM19A1__ gene in the mouse brain. The __FAM19A1__ expression was observed in several brain regions starting during embryonic brain development. As the brain matured, the __FAM19A1__ expression was detected in the pyramidal cells of cortical layers 2/3 and 5 and in several limbic areas, including the hippocampus and the amygdala. FAM19A1-deficient mice were used to evaluate the physiological contribution of FAM19A1 to various brain functions. In behavior analysis, FAM19A1-deficient mice exhibited several abnormal behaviors, including hyperactive locomotor behavior, long-term memory deficits and fear acquisition failure. These findings provide insight into the potential contributions of FAM1
Who reads The unique expression profile of FAM19A1 in the mouse brain and its association with hyperactivity, long-term memory and fear acquisition?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Yong, Hyo Jeong; Ha, Nui; Cho, Eun Bee; Yun, Seongsik; Kim, Hyun; Hwang, Jong-Ik; Seong, Jae Young
- Publisher
- Springer Science and Business Media LLC; London: Nature Publishing Group; [London]: Springer Nature; Nature Publishing Group; Society for Mining, Metallurgy and Exploration Inc.; Research Square; Springer Nature; Island Press (ISSN 2045-2322)
- Published
- 2020
- Language
- EN
- ISBN
- 9784159802067
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)