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Seizure Evolution and Outcome in Pediatric Autoimmune Encephalitis by Hyewon Woo; Youngkyu Shim; Jong-Hee Chae; Ki Joong Kim; Byung Chan Lim is a Medicine article available to read on EtoBox.

What is Seizure Evolution and Outcome in Pediatric Autoimmune Encephalitis about?

Background Our study aimed to characterize seizure incidence and seizure outcome of pediatric autoimmune encephalitis (AE) focusing on subgroup analysis based on antibody (Ab). Methods Among 110 pediatric patients with AE, we compared seizure characteristics and outcomes in 68 patients with seizure, who satisfied the proposed criteria of pediatric AE. Accordingly, patients were classified into three groups, anti-myelin oligodendrocyte glycoprotein (anti-MOG) AE, anti-N-methyl-D-aspartic acid receptor (anti-NMDAR) AE, and Ab-negative AE. Univariate and multivariate analyses were performed to evaluate the risk factors for postencephalitic seizures, defined as persisting seizures six months after onset. Results Seizure incidence in the anti-NMDAR (88.9%) and Ab-negative (71.1%) groups differed from anti-MOG group (37.8%). Median seizure frequency within six months was higher in the Ab-negative group (6.0, interquartile range [IQR] 3.0 to 13.0) than in the anti-NMDAR group (3.0, IQR 2.0 to 4.5) and anti-MOG group (2.0, IQR 1.0 to 5.0). Patients in the Ab-negative group tended to develop postencephalitic seizures more frequently and have a lower seizure freedom rate than those in the an

Who reads Seizure Evolution and Outcome in Pediatric Autoimmune Encephalitis?

Author

Hyewon Woo; Youngkyu Shim; Jong-Hee Chae; Ki Joong Kim; Byung Chan Lim

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Medicine (Health Sciences)