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Can I read Molecular Analyses of Triple-negative Breast Cancer in the Young and Elderly on EtoBox?
Molecular Analyses of Triple-negative Breast Cancer in the Young and Elderly by Mattias Aine; Ceren Boyaci; Johan Hartman; Jari Häkkinen; Shamik Mitra; Ana Bosch Campos; Emma Nimeus; Anna Ehinger; Johan Vallon-Christersson; Åke Borg; Johan Staaf is a Medicine article available to read on EtoBox.
What is Molecular Analyses of Triple-negative Breast Cancer in the Young and Elderly about?
## Abstract ## Background Breast cancer in young adults has been implicated with a worse outcome. Analyses of genomic traits associated with age have been heterogenous, likely because of an incomplete accounting for underlying molecular subtypes. We aimed to resolve whether triple-negative breast cancer (TNBC) in younger versus older patients represent similar or different molecular diseases in the context of genetic and transcriptional subtypes and immune cell infiltration. ## Patients and methods In total, 237 patients from a reported population-based south Swedish TNBC cohort profiled by RNA sequencing and whole-genome sequencing (WGS) were included. Patients were binned in 10-year intervals. Complimentary PD-L1 and CD20 immunohistochemistry and estimation of tumor-infiltrating lymphocytes (TILs) were performed. Cases were analyzed for differences in patient outcome, genomic, transcriptional, and immune landscape features versus age at diagnosis. Additionally, 560 public WGS breast cancer profiles were used for validation. ## Results Median age at diagnosis was 62 years (range 26–91). Age was not associated with invasive disease-free survival or overall survival after adjuvant c
Who reads Molecular Analyses of Triple-negative Breast Cancer in the Young and Elderly?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Mattias Aine; Ceren Boyaci; Johan Hartman; Jari Häkkinen; Shamik Mitra; Ana Bosch Campos; Emma Nimeus; Anna Ehinger; Johan Vallon-Christersson; Åke Borg; Johan Staaf
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)