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Using mechanism-based combinations of H~2~S-donors to maximize the cardioprotective action of H~2~S by Stella Ravani; Athanasia Chatzianastasiou; Andreas Papapetropoulos is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract H~2~S-donors are cardioprotective in ischemia/reperfusion (I/R) injury. Some H~2~S-donors exert their beneficial effects in a nitric oxide (NO)-dependent manner, while others act using NO-independent pathways. The aims of the present study were to (i) evaluate whether H~2~S-donors with distinct pharmacodynamic properties act synergistically in I/R injury and (ii) determine if H~2~S-donors remain cardioprotective in obese mice. C57BL/6 mice were subjected to 30 min of ischemia followed by 120 min of reperfusion. Donors were administered intravenously at the end of ischemia (Na~2~S: 1 μmol/kg, GYY4137: 25 μmol/kg, AP39: 0,25 μmol/kg), while the 3-mercaptopyruvate sulfurtransferase (10 mg/kg) inhibitor was given intraperitonially 1 h prior to ischemia. Infarct size was estimated by 2,3,5-triphenyltetrazolium staining, while the area at risk was calculated using Evans blue. All three donors reduced infarct size when administered as a sole treatment. Co-administration of Na~2~S/GYY4137, as well as Na~2~S/AP39 reduced further the I/R injury, beyond what was observed with each individual donor. Since inhibition of the H~2~S-producing enzyme 3-mercaptopyruvate sulfurtransferase

Who reads Using mechanism-based combinations of H~2~S-donors to maximize the cardioprotective action of H~2~S?

Author

Stella Ravani; Athanasia Chatzianastasiou; Andreas Papapetropoulos

Publisher

Springer

Published

2023

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)