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Can I read Metabolic Syndrome: does this influence breast cancer outcomes in the triple-negative population? on EtoBox?
Metabolic Syndrome: does this influence breast cancer outcomes in the triple-negative population? by Kaitlyn Kennard; Meghan E. Buckley; Lina M. Sizer; Sharon Larson; William B. Carter; Thomas G. Frazier; Ned Z. Carp is a Medicine article available to read on EtoBox.
What is Metabolic Syndrome: does this influence breast cancer outcomes in the triple-negative population? about?
## Introduction: Metabolic syndrome (ms) is defined by having at least 3 of 4 components: obesity, dyslipidemia, hypertension (htn), and diabetes. prior studies analyzed the individual components of ms for all breast cancers which are predominantly hormone positive. our study is the first to evaluate ms in triple-negative breast cancer (tnbc). ## Methods: A retrospective review of tnbc from 2007 to 2013 identified 177 patients with complete information for statistical analysis. cox proportional hazards models were used to test the association between ms, disease-free survival (dfs), and overall survival (os). ## Results: 48 (27%) patients had ms. after controlling for age, race, pathologic stage, surgery type, and additional comorbidities outside of ms, ms was significantly associated with poorer dfs (adjusted hr: 2.24, p = 0.030), but not associated with os (adjusted hr: 1.92, p = 0.103). htn was significantly associated with poorer dfs (adjusted hr: 3.63, p = 0.006) and os (adjusted hr: 3.45, p = 0.035) in the univariable and multivariable analyses. diabetes was not associated with worse os or dfs. the 5-year age-adjusted os rates for 60-year-old patients with and without diabete
Who reads Metabolic Syndrome: does this influence breast cancer outcomes in the triple-negative population??
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Kaitlyn Kennard; Meghan E. Buckley; Lina M. Sizer; Sharon Larson; William B. Carter; Thomas G. Frazier; Ned Z. Carp
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)