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Efficacy of Desulfated Heparin Mitigating Inflammation in Rat Burn Wound Model by Thiagavathi S. Ramyaa Lakshmi; Natesan Shanmugasundaram; Seetharaman Shanmuganathan; Mary Babu is a Medicine article available to read on EtoBox.

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## Abstract During skin repair, leukocyte infiltration is the principal inflammatory response which is instrumental in triggering growth factor and cytokine signals that orchestrate together to recruit cells necessary for healing. In severe wounds like burn, when acute inflammation becomes chronic, intervention is required to control inflammation so as to hasten the process of healing. Heparin, a known anticoagulant also possesses anti‐inflammatory activity by its ability to interfere with the adhesion of leukocytes to the endothelium. Desulfated heparins (DSH) have subdued anticoagulant activity while possessing increased anti‐inflammatory activity. Among which 2,3 DSH is found to have marked potency as an anti‐inflammatory agent and has been utilized for this study. In this investigation, a controlled delivery system was designed by incorporating 2,3 DSH in microspheres and embedding in collagen matrix which could serve as a wound dressing in burns. __In vivo__ evaluation of healing process was ascertained in rat burn wound model by qualitative and quantitative estimation of proinflammatory cytokines in serum and granulation tissue and collagen turnover was also assessed as heali

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Author

Thiagavathi S. Ramyaa Lakshmi; Natesan Shanmugasundaram; Seetharaman Shanmuganathan; Mary Babu

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1552-4973)

Published

2011

Language

EN

Field

Medicine (Health Sciences)