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GABAB receptor gene expression in monkey thalamus by Muoz, Alberto; Huntsman, Molly M.; Jones, Edward G. is a Neuroscience article available to read on EtoBox.

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Expression of ␥-amino butyric acid type B (GABA B ) receptor gene transcripts was examined in the macaque monkey thalamus by in situ hybridization, using monkey-specific cRNA probes. GABA B transcript expression was widespread and of much higher density in the dorsal thalamus than in the reticular nucleus and other parts of the ventral thalamus and was highest in the epithalamus. In the dorsal thalamus, highest mRNA levels were found in the anteroventral nucleus and in the parafascicular nucleus. Sensory relay nuclei showed moderate GABA B mRNA levels. Neurons of all sizes were labeled, suggesting expression in relay cells and interneurons, and there was no labeling of neuroglial cells. Following 10-day periods of monocular deprivation, levels of GABA B mRNA were decreased in the deprived magno-and parvo-cellular laminae of the dorsal lateral geniculate nuclei, indicating activity-dependent regulation. High levels of GABA B receptors in the dorsal thalamus are likely to reflect the high density of synaptic inputs from the reticular nucleus while low expression in the reticular nucleus implies weak, GABA B -mediated intrareticular inhibition.

Who reads GABAB receptor gene expression in monkey thalamus?

Author

Muoz, Alberto; Huntsman, Molly M.; Jones, Edward G.

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0021-9967)

Published

1998

Language

EN

Field

Neuroscience (Life Sciences)