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RNA-mediated transfer of tumor immunity —A new model for the immunotherapy of cancer by Peter J. Deckers; Yosef H. Pilch is a Medicine article available to read on EtoBox.

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The adoptive transfer of tumor-specific transplantation immunity was accomplished in a syngeneic rat tumor-host system. Rats which received intravenous injections of spleen cells from Fisher 344/N rats immunized by amputation of growing isografts of a benz(a)pyrene-induced fibrosarcoma (BP-1R) manifested a significant decrease in the incidence of development of tumor isografts. T h e intravenous administration of normal spleen cells to syngeneic rats was not effective. I n other experiments, Fisher 344JN rats were immunized in a similar manner, and RNA was extracted from their spleens. Normal F-344/N spleen cells were incubated with this "immune" RNA, and injected intravenously into F-344/N rats which were then challenged with viable BP-IR cells. A marked decrease in tumor growth rate resulted. T h e intravenous administration of spleen cells incubated with RNA extracted from the spleens of unimmunized rats was ineffective. I n the same tumor-host system, RNA, extracted from the nodes and spleens of guinea pigs immunized with the BP-IR sarcoma, was mixed with sodium dextran sulfate, a potent inhibitor of ribonuclease, and administered to normal F-344," rats which were then challeng

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Author

Peter J. Deckers; Yosef H. Pilch

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)

Published

1971

Language

EN

Field

Medicine (Health Sciences)