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Mining the Metabolome and the Agricultural and Pharmaceutical Potential of Sea Foam-Derived Fungi by Oppong-Danquah, Ernest; Passaretti, Cristina; Chianese, Orazio; BlÃ1⁄4mel, Martina; Tasdemir, Deniz is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Mining the Metabolome and the Agricultural and Pharmaceutical Potential of Sea Foam-Derived Fungi about?
Sea foam harbors a diverse range of fungal spores with biological and ecological relevance in marine environments. Fungi are known as the producers of secondary metabolites that are used in health and agricultural sectors, however the potentials of sea foam-derived fungi have remained unexplored. In this study, organic extracts of six foam-derived fungal isolates belonging to the genera __Penicillium__, __Cladosporium__, __Emericellopsis__ and __Plectosphaerella__ were investigated for their antimicrobial activity against plant and human pathogens and anticancer activity. In parallel, an untargeted metabolomics study using UPLC-QToF–MS/MS-based molecular networking (MN) was performed to unlock their chemical inventory. __Penicillium__ strains were identified as the most prolific producers of compounds with an average of 165 parent ions per strain. In total, 49 known mycotoxins and functional metabolites were annotated to specific and ubiquitous parent ions, revealing considerable chemical diversity. This allowed the identification of putative new derivatives, such as a new analog of the antimicrobial tetrapeptide, fungisporin. Regarding bioactivity, the __Penicillium__ sp. isolate
Who reads Mining the Metabolome and the Agricultural and Pharmaceutical Potential of Sea Foam-Derived Fungi?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Oppong-Danquah, Ernest; Passaretti, Cristina; Chianese, Orazio; BlÃ1⁄4mel, Martina; Tasdemir, Deniz
- Publisher
- MDPI Publishing; MDPI AG; Multidisciplinary Digital Publishing Institute (MDPI); Basel: MDPI, 2003- (ISSN 1660-3397)
- Published
- 2020
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)