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What is Cell-Free DNA and HLA Mismatch in Kidney Transplants about?

This study investigates the relationship between donor-derived cell-free DNA (dd-cfDNA) levels and HLA class II eplet mismatch load in kidney transplant recipients. It found that elevated dd-cfDNA levels, particularly above 1.0%, correlate with increased risk of acute rejection and graft failure, with the HLA-DQB1 eplet mismatch being a significant pretransplant variable. The findings suggest that combining dd-cfDNA measurement with HLA eplet mismatch assessment could enhance the prediction of allograft out

Author

evanssm

Language

EN