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Cholinergic synapses in the central nervous system: Studies of the immunocytochemical localization of choline acetyltransferase by Carolyn R. Houser is a Materials Science article available to read on EtoBox.

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## Abstract Cholinergic synapses can be identified in immunocytochemical preparations by the use of monoclonal antibodies and specific antisera to choline acetyltransferase (ChAT), the synthesizing enzyme for acetylcholine (ACh) and a specific marker for cholinergic neurons. Electron microscopic studies demonstrate that the fibers and varicosities observed in light microscopic preparations of many brain regions are small‐diameter unmyelinated axons and vesicle‐containing boutons. The labeled boutons generally contain clear vesicles and one or more mitochondrial profiles. Many of these boutons form synaptic contacts, and the synapses are frequently of the symmetric type, displaying thin postsynaptic densities and relatively short contact zones. However, ChAT‐labeled synapses with asymmetric junctions are also observed, and their frequency varies among different brain regions. Unlabeled dendritic shafts are the most common postsynaptic elements in virtually all regions examined although other neuronal elements, including dendritic spines and neuronal somata, also receive some cholinergic innervation. ChAT‐labeled boutons form synaptic contacts with several different types of unlabele

Who reads Cholinergic synapses in the central nervous system: Studies of the immunocytochemical localization of choline acetyltransferase?

Author

Carolyn R. Houser

Publisher

Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0741-0581)

Published

1990

Language

EN

Field

Materials Science (Physical Sciences)