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Can I read A Critical Structural Determinant of Opioid Receptor Interaction with Phenolic 5-Phenylmorphans on EtoBox?
A Critical Structural Determinant of Opioid Receptor Interaction with Phenolic 5-Phenylmorphans by In Jong Kim; Christina M Dersch; Richard B Rothman; Arthur E Jacobson; Kenner C Rice is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is A Critical Structural Determinant of Opioid Receptor Interaction with Phenolic 5-Phenylmorphans about?
The opioid receptor binding affinities of N-methyl-and N-phenethyl-5-phenylmorphans with a meta-hydroxy substituent [3-(2-methyl-2-azabicyclo[3.3.1]non-5-yl)-phenol (1a), and 3-(2-phenethyl-2-azabicyclo[3.3.1]non-5-yl)-phenol (1b)] were compared with the affinities of four new ligands bearing an ortho- 3a), and 4-(2-phenethyl-2-azabicyclo[3.3.1]non-5-yl)-phenol (3b)) that were synthesized from 2-bromoanisole or the known 2-methyl-5phenyl-2-azabicyclo[3.3.1]nonane (13), respectively. The data indicated that either the electronic state of the phenolic ring is critical for the ligand's interaction with an opioid receptor, or that there must be a specific distance and angle for a hydrogen bond between the phenolic moiety and an amino acid in the binding domain that cannot be altered.
Who reads A Critical Structural Determinant of Opioid Receptor Interaction with Phenolic 5-Phenylmorphans?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- In Jong Kim; Christina M Dersch; Richard B Rothman; Arthur E Jacobson; Kenner C Rice
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0968-0896)
- Published
- 2004
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)