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Omiganan Enhances Imiquimod‐Induced Inflammatory Responses in Skin of Healthy Volunteers by Tessa Niemeyer‐van der Kolk; Salma Assil; Thomas P. Buters; Melanie Rijsbergen; Erica S. Klaassen; Gary Feiss; Edwin Florencia; Errol P. Prens; Jacobus Burggraaf; Martijn B.A. Doorn; Robert Rissmann; Matthijs Moerland is a Medicine article available to read on EtoBox.

What is Omiganan Enhances Imiquimod‐Induced Inflammatory Responses in Skin of Healthy Volunteers about?

Omiganan (OMN; a synthetic cationic peptide) and imiquimod (IMQ; a TLR7 agonist) have synergistic effects on interferon responses __in vitro__. The objective of this study was to translate this to a human model for proof‐of‐concept, and to explore the potential of OMN add‐on treatment for viral skin diseases. Sixteen healthy volunteers received topical IMQ, OMN, or a combination of both for up to 4 days on tape‐stripped skin. Skin inflammation was quantified by laser speckle contrast imaging and 2D photography, and molecular and cellular responses were analyzed in biopsies. IMQ treatment induced an inflammatory response of the skin. Co‐treatment with OMN enhanced this inflammatory response to IMQ, with increases in perfusion (+17.1%; 95% confidence interval (CI) 5.6%–30%; __P__ < 0.01) and erythema (+1.5; 95% CI 0.25%–2.83; __P__ = 0.02). Interferon regulatory factor‐driven and NFκB‐driven responses following TLR7 stimulation were enhanced by OMN (increases in IL‐6, IL‐10, MXA, and IFNɣ), and more immune cell infiltration was observed (in particular CD4+, CD8+, and CD14+ cells). These findings are in line with the earlier mechanistic __in vitro__ data, and support evaluation of imi

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Author

Tessa Niemeyer‐van der Kolk; Salma Assil; Thomas P. Buters; Melanie Rijsbergen; Erica S. Klaassen; Gary Feiss; Edwin Florencia; Errol P. Prens; Jacobus Burggraaf; Martijn B.A. Doorn; Robert Rissmann; Matthijs Moerland

Publisher

Wiley

Published

2020

Language

EN

Field

Medicine (Health Sciences)