Can I read 2-Aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3-b]pyridines as broad-spectrum inhibitors of human herpesvirus polymerases on EtoBox?

2-Aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3-b]pyridines as broad-spectrum inhibitors of human herpesvirus polymerases by Mark E. Schnute; David J. Anderson; Roger J. Brideau; Fred L. Ciske; Sarah A. Collier; Michele M. Cudahy; MariJean Eggen; Michael J. Genin; Todd A. Hopkins; Thomas M. Judge; Euibong J. Kim; Mary L. Knechtel; Sajiv K. Nair; James A. Nieman; Nancee L. Oien; Allen Scott; Steven P. Tanis; Valerie A. Vaillancourt; Michael W. Wathen; Janet L. Wieber is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is 2-Aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3-b]pyridines as broad-spectrum inhibitors of human herpesvirus polymerases about?

A novel series of 2-aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamides have been identified as potent antivirals against human herpesviruses. These compounds demonstrate broad-spectrum inhibition of the herpesvirus polymerases HCMV, HSV-1, EBV, and VZV with high specificity compared to human DNA polymerases.

Who reads 2-Aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3-b]pyridines as broad-spectrum inhibitors of human herpesvirus polymerases?

Author

Mark E. Schnute; David J. Anderson; Roger J. Brideau; Fred L. Ciske; Sarah A. Collier; Michele M. Cudahy; MariJean Eggen; Michael J. Genin; Todd A. Hopkins; Thomas M. Judge; Euibong J. Kim; Mary L. Knechtel; Sajiv K. Nair; James A. Nieman; Nancee L. Oien; Allen Scott; Steven P. Tanis; Valerie A. Vaillancourt; Michael W. Wathen; Janet L. Wieber

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)

Published

2007

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)