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Structure and in vitro antitumor activity evaluation of brominated diterpenes from the red alga Sphaerococcus coronopifolius by Vangelis Smyrniotopoulos; Constantinos Vagias; Céline Bruyère; Delphine Lamoral-Theys; Robert Kiss; Vassilios Roussis is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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A novel bromoditerpene methyl ketone (1), two new bromoditerpene alcohols featuring a neodolastane (2), and a bromocorodienol skeleton (3), along with 13 previously reported metabolites (4-16) were isolated from the organic extract of Sphaerococcus coronopifolius collected from the rocky coasts of Corfu island in the Ionian Sea. The structures of the new natural products, as well as their relative stereochemistry, were elaborated on the basis of extensive spectral analysis, including 2D NMR experiments. The absolute stereochemistry of metabolite 3 was determined using the modified Mosher's method. The isolated metabolites were evaluated for their antitumoral activity against four human apoptosis-resistant (U373, A549, SKMEL-28, OE21) and two human apoptosis-sensitive (PC-3, LoVo) cancer cell lines with IC(50) in vitro growth inhibitory concentrations in the range 3-100 microM.

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Author

Vangelis Smyrniotopoulos; Constantinos Vagias; Céline Bruyère; Delphine Lamoral-Theys; Robert Kiss; Vassilios Roussis

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0968-0896)

Published

2010

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)