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Can I read The relation between cell division rate and ^3^HTdR incorporation in organ culture on EtoBox?
The relation between cell division rate and ^3^HTdR incorporation in organ culture by John D. Simnett; Jean M. Fisher is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is The relation between cell division rate and ^3^HTdR incorporation in organ culture about?
## Abstract Rates of incorporation of labelled thymidine (RIT), radioautographic labelling index for DNA synthesis (LI) and mitotic incidence following colcemid metaphase arrest (MI) were measured in organ cultures of newborn and adult rat lung. In adult cultures these three parameters correlated well, being low after explantation and reaching a maximum after two to three days. In newborn cultures RIT fell several fold over the first 24 hours after explantation and, in this respect, did not correlate with LI and MI. The changes in RIT over the first 24 hours appear to be due to changes in the degree of competition between endogenous TdR and exogenous labelled TdR, probably caused by leakage of the intracellular thymidine pool following explantation. The report emphasizes the need to check RIT data against radioautographic evidence before accepting it as an index of DNA synthesis.
Who reads The relation between cell division rate and ^3^HTdR incorporation in organ culture?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- John D. Simnett; Jean M. Fisher
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0021-9541)
- Published
- 1973
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)