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Preparation and characterization of caffeic acid grafted chitosan/CPTMS hybrid scaffolds by Jia Ching Shiu; Ming-Hua Ho; Shu-Huei Yu; An-Chong Chao; Yu-Ru Su; Wei-Jen Chen; Zu-Chian Chiang; Wen Pin Yang is a Materials Science article available to read on EtoBox.
What is Preparation and characterization of caffeic acid grafted chitosan/CPTMS hybrid scaffolds about?
In this study, preparation and characterization of caffeic acid grafted chitosan (CTS)/(3-chloropropyl)trimethoxysilane (CPTMS) hybrid scaffolds were investigated. The grafting of caffeic acid onto CSC1.0 (CTS/ CPTMS hybrid scaffold prepared in weight ratio of 1:1) not only increased its compressive strength but also enhanced its antibacterial, antioxidant and anti-cancer property. The caffeic acid grafted scaffolds exhibited higher anti Staphylococcus aureus and scavenging 2,2-diphenyl-1-picrylhydrazyl (DPPH) property than CSC1.0 did. The compressive strength of the caffeic acid grafted scaffolds is 0.54$0.65 MPa, which was higher than that of CTS scaffold (0.14 MPa) and CSC1.0 (0.33 MPa). In culturing human osteosarcoma UMR-106 cells, the caffeic acid grafted scaffolds showed inhibitions on cell growth, alkaline phosphatase activity and cell attachment of UMR-106 cells. Caffeic acid grafting approach could be very promising for chitosan scaffolds to be used in hard-tissue engineering application.
Who reads Preparation and characterization of caffeic acid grafted chitosan/CPTMS hybrid scaffolds?
It is typically read by researchers, students, and practitioners in Materials Science.
- Author
- Jia Ching Shiu; Ming-Hua Ho; Shu-Huei Yu; An-Chong Chao; Yu-Ru Su; Wei-Jen Chen; Zu-Chian Chiang; Wen Pin Yang
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0144-8617)
- Published
- 2010
- Language
- EN
- Field
- Materials Science (Physical Sciences)