Can I read Rotating Waves During Human Sleep Spindles Organize Global Patterns of Activity That Repeat Precisely Through the Night on EtoBox?

Rotating Waves During Human Sleep Spindles Organize Global Patterns of Activity That Repeat Precisely Through the Night by Lyle Muller; Giovanni Piantoni; Dominik Koller; Sydney S Cash; Eric Halgren; Terrence J Sejnowski is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Rotating Waves During Human Sleep Spindles Organize Global Patterns of Activity That Repeat Precisely Through the Night about?

During sleep, the thalamus generates a characteristic pattern of transient, 11-15 Hz sleep spindle oscillations, which synchronize the cortex through large-scale thalamocortical loops. Spindles have been increasingly demonstrated to be critical for sleep-dependent consolidation of memory, but the specific neural mechanism for this process remains unclear. We show here that cortical spindles are spatiotemporally organized into circular wave-like patterns, organizing neuronal activity over tens of milliseconds, within the timescale for storing memories in large-scale networks across the cortex via spike-time dependent plasticity. These circular patterns repeat over hours of sleep with millisecond temporal precision, allowing reinforcement of the activity patterns through hundreds of reverberations. These results provide a novel mechanistic account for how global sleep oscillations and synaptic plasticity could strengthen networks distributed across the cortex to store coherent and integrated memories.

Who reads Rotating Waves During Human Sleep Spindles Organize Global Patterns of Activity That Repeat Precisely Through the Night?

Author

Lyle Muller; Giovanni Piantoni; Dominik Koller; Sydney S Cash; Eric Halgren; Terrence J Sejnowski

Publisher

eLife Sciences Publications, Ltd

Published

2016

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)