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Hypnozoite dynamics for Plasmodium vivax malaria: the epidemiological effects of radical cure by Mehra, Somya; Stadler, Eva; Khoury, David; McCaw, James M.; Flegg, Jennifer A. is a scholarly article available to read on EtoBox.

What is Hypnozoite dynamics for Plasmodium vivax malaria: the epidemiological effects of radical cure about?

Malaria is a mosquito-borne disease with a devastating global impact. Plasmodium vivax is a major cause of human malaria beyond sub-Saharan Africa. Relapsing infections, driven by a reservoir of liver-stage parasites known as hypnozoites, present unique challenges for the control of P. vivax malaria. Following indeterminate dormancy periods, hypnozoites may activate to trigger relapses. Clearance of the hypnozoite reservoir through drug treatment (radical cure) has been proposed as a potential tool for the elimination of P. vivax malaria. Here, we introduce a stochastic, within-host model to jointly characterise hypnozoite and infection dynamics for an individual in a general transmission setting, allowing for radical cure. We begin by extending an existing activation-clearance model for a single hypnozoite, adapted to both short- and long-latency strains, to include drug treatment. We then embed this activation-clearance model in an epidemiological framework accounting for repeated mosquito inoculation and the administration of radical cure. By constructing an open network of infinite server queues, we derive analytic expressions for several quantities of epidemiological significa

Author

Mehra, Somya; Stadler, Eva; Khoury, David; McCaw, James M.; Flegg, Jennifer A.

Published

2021

Language

EN