Can I read Concise total synthesis of nauclefine: A regioselective Rhodium(III)-catalyzed oxidative C-H activation approach on EtoBox?

Concise total synthesis of nauclefine: A regioselective Rhodium(III)-catalyzed oxidative C-H activation approach by Kaiqi Chen; Haoran Dong; Jin Wang; Xiaoguang Lei is a Chemistry article available to read on EtoBox.

What is Concise total synthesis of nauclefine: A regioselective Rhodium(III)-catalyzed oxidative C-H activation approach about?

A concise total synthesis of the plant indole alkaloid natural product nauclefine (1) was accomplished from the commercially available nicotinic acid and the known compound in 6 steps. The synthesis features a regioselective rhodium(III)-catalyzed oxidative C-H activation for the construction of the key naphthyridinone ring. The intramolecular Mitsunobu-type annulation, allylic oxidation and Fischer indolization were used successively to complete the total synthesis of nauclefine (1).

Who reads Concise total synthesis of nauclefine: A regioselective Rhodium(III)-catalyzed oxidative C-H activation approach?

Author

Kaiqi Chen; Haoran Dong; Jin Wang; Xiaoguang Lei

Publisher

Elsevier BV

Published

2021

Language

EN

Field

Chemistry (Physical Sciences)