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Can I read A High-throughput Screening Platform for Inhibitors of the Riboflavin Biosynthesis Pathway on EtoBox?
A High-throughput Screening Platform for Inhibitors of the Riboflavin Biosynthesis Pathway by Johannes Kaiser; Boris Illarionov; Felix Rohdich; Wolfgang Eisenreich; Sabine Saller; Jan Van den Brulle; Mark Cushman; Adelbert Bacher; Markus Fischer is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is A High-throughput Screening Platform for Inhibitors of the Riboflavin Biosynthesis Pathway about?
3,4-Dihydroxy-2-butanone 4-phosphate synthase, 6,7-dimethyl-8-ribityllumazine synthase, and riboflavin synthase of the riboflavin biosynthetic pathway are potential targets for novel antiinfective drugs. This article describes a platform for high-throughput screening for inhibitors of these enzymes. The assays can be monitored photometrically and have been shown to be robust, as indicated by Z factors 0.87. A (13)C NMR assay for hit verification of 3,4-dihydroxy-2-butanone 4-phosphate synthase inhibitors is also reported.
Who reads A High-throughput Screening Platform for Inhibitors of the Riboflavin Biosynthesis Pathway?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Johannes Kaiser; Boris Illarionov; Felix Rohdich; Wolfgang Eisenreich; Sabine Saller; Jan Van den Brulle; Mark Cushman; Adelbert Bacher; Markus Fischer
- Publisher
- Elsevier Science; Elsevier ; Elsevier Inc.; Elsevier BV (ISSN 0003-2697)
- Published
- 2007
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)