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Aggressive Surgical Policies in a Retrospectively Reviewed Single-Institution Case Series of Retroperitoneal Soft Tissue Sarcoma Patients by Alessandro Gronchi; Salvatore Lo Vullo; Marco Fiore; Chiara Mussi; Silvia Stacchiotti; Paola Collini; Laura Lozza; Elisabetta Pennacchioli; Luigi Mariani; Paolo Giovanni Casali is a Medicine article available to read on EtoBox.
What is Aggressive Surgical Policies in a Retrospectively Reviewed Single-Institution Case Series of Retroperitoneal Soft Tissue Sarcoma Patients about?
## Purpose To explore whether the adoption of a systematic attempt to perform wider resections may lead to prognostic improvements in retroperitoneal soft tissue sarcoma (RSTS). ## Patients and Methods Two hundred eighty-eight consecutive patients who were surgically treated at a single referral center were analyzed. Because a shift toward a systematic, more aggressive surgical approach (ie, liberal en bloc resection of adjacent organs) was in place from 2002 onward, patients were divided in two groups accordingly. Overall survival, crude cumulative incidence (CCI) of local recurrence, and distant metastases were estimated. Univariable and multivariable analyses were carried out. ## Results Patients who underwent operation in the early period had a 5-year local recurrence rate of 48% compared with 28% for patients who were treated in the recent period. The number of distant metastases was greater in the recent group (22% v 13%), and overall survival was similar. In addition to the period of treatment, important independent determinants for local recurrence-free survival were histologic grade, histologic subtype, and radiation therapy. Overall, liposarcomas and grades 1 to 2 tumors
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- Author
- Alessandro Gronchi; Salvatore Lo Vullo; Marco Fiore; Chiara Mussi; Silvia Stacchiotti; Paola Collini; Laura Lozza; Elisabetta Pennacchioli; Luigi Mariani; Paolo Giovanni Casali
- Publisher
- American Society of Clinical Oncology (ASCO)
- Published
- 2009
- Language
- EN
- Field
- Medicine (Health Sciences)