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Evaluation of the Usefulness of Biomarkers for Cardiac and Skeletal Myotoxicity in Rats by Yutaka Tonomura; Yoko Mori; Mikinori Torii; Takeki Uehara is a Environmental Science article available to read on EtoBox.

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Since cardiac and skeletal myotoxicity affect the development of drug candidates, it is important to detect their toxicity at an early stage of drug development. For that purpose, in this study, the usefulness of several cardiac and skeletal myotoxic biomarkers in blood were evaluated using two rat models treated intraperitoneally with an acetylcholinesterase inhibitor carbofuran (CAF) or a synthetic catecholamine isoproterenol (ISO). The biomarkers assayed were fatty acid binding protein 3 (Fabp3), myosin light chain 1 (MLC1), cardiac troponin I (cTnI), cardiac troponin T (cTnT), aspartate transaminase (AST), lactate dehydrogenase (LDH) and creatine kinase (CK). CAF and ISO treatment of rats induced greater increases in the levels of Fabp3, MLC1, cTnI and cTnT than in the levels of AST, LDH and CK. A kinetic analysis indicated that the levels of all of the biomarkers had returned to the basal level by 24 h after drug administration. Pathological examination revealed lesions in the heart, mainly at the left ventricle and septum, in both CAF-and ISO-treated rats. CAF-treated rats showed widespread lesions of skeletal muscle that were independent of muscle fiber type, while in ISO-tr

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Author

Yutaka Tonomura; Yoko Mori; Mikinori Torii; Takeki Uehara

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0300-483X)

Published

2009

Language

EN

Field

Environmental Science (Life Sciences)